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Thursday, Apr.25, 2024
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| miRNA: |
hsa-miR-155 |
| Disease: |
Burkitt lymphoma |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
AGTR1 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Expression of BIC is regulated by the BcR signaling pathway in a PKC and NF-kB-dependent manner. Classical Burkitt lymphoma cell lines, in contrast to normal B cells, Hodgkin's lymphoma cell lines and HEK293 cells,are not able to process BIC to mature miR-155.This indicates two levels of regulation of mature miR-155 expression, one at the transcriptional and one at the processing level. |
Reference:
Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma. | PMID:17173072
Kluiver J, van den Berg A, de Jong D, Blokzijl T, Harms G, Bouwman E, Jacobs S, Poppema S, Kroesen BJ.
Oncogene. 2007 May 31;26(26):3769-76. Epub 2006 Dec 18. |
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