Friday, May.3, 2024
miRNA:

hsa-let-7e
Disease:

lung cancer

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc
Expression pattern of miRNA:

down-regulated

Validated targets of miRNA from the reference:

HMGA2

Validated targets of miRNA from TarBase:

SMC1L1 : More...
Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

let-7 reduces the expression of HMGA2 and cell proliferation.

 

 

Reference:

The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. | PMID:17437991
Lee YS, Dutta A.
Genes Dev. 2007 May 1;21(9):1025-30. Epub 2007 Apr 16.

 
 
 
 
　 miRBase
　 Tarbase
　 miRGen
　 miRGator
　 CCBB
　 MicroRNA.org
　 miRRim
  miRNAMap 2.0
 
 
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