| miRNA: |
hsa-miR-223 |
| Disease: |
acute promyelocytic leukemia (APL) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
NFIA : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: The expression levels of a specific miR-223 correlate with the differentiation fate of myeloid precursors. The activation of both pathways of transcriptional regulation by the myeloid lineage-specific transcription factor C/EBPalpha (CCAAT/enhancer-binding protein-alpha), and posttranscriptional regulation by miR-223 appears essential for granulocytic differentiation and clinical response of acute promyelocytic leukemia (APL) blasts to all-trans retinoic acid (ATRA). |
Reference:
Emerging role for microRNAs in acute promyelocytic leukemia. | PMID:17217039
Nervi C, Fazi F, Rosa A, Fatica A, Bozzoni I.
Curr Top Microbiol Immunol. 2007;313:73-84. |
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