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Wednesday, Apr.24, 2024
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| miRNA: |
hsa-miR-223 |
| Disease: |
neutrophilia |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
Mef2c |
Validated targets of miRNA from TarBase: |
NFIA : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: myeloid-specific miR-223 negatively regulates progenitor proliferation and granulocyte differentiation and activation. miR-223 mutant mice have an expanded granulocytic compartment resulting from a cell-autonomous increase in the number of granulocyte progenitors. Mef2c, a transcription factor that promotes myeloid progenitor proliferation, is a target of miR-223, and that genetic ablation of Mef2c suppresses progenitor expansion and corrects the neutrophilic phenotype in miR-223 null mice. In addition, granulocytes lacking miR-223 are hypermature, hypersensitive to activating stimuli and display increased fungicidal activity. |
Reference:
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. | PMID:18278031
Johnnidis JB, Harris MH, Wheeler RT, Stehling-Sun S, Lam MH, Kirak O, Brummelkamp TR, Fleming MD, Camargo FD.
Nature. 2008 Feb 28;451(7182):1125-9. Epub 2008 Feb 17. |
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