Thursday, Mar.28, 2024
miRNA:

hsa-miR-223

Disease:

acute lymphoblastic leukemia (ALL)

Relationship type:

Unspecified

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

down-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

NFIA : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

miR-128a and -128b are significantly overexpressed, whereas let-7b and miR-223 are significantly downregulated in ALL compared with AML. They are the most discriminatory miRNAs between ALL and AML. Using the expression signatures of a minimum of two of these miRNAs resulted in an accuracy rate of >95% in the diagnosis of ALL and AML.

 

 

Reference:

MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. | PMID:18056805
Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly MB, Wang Y, Qian Z, Jin J, Zhang Y, Bohlander SK, Le Beau MM, Larson RA, Golub TR, Rowley JD, Chen J.
Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19971-6. Epub 2007 Dec 4.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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