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Friday, Apr.19, 2024
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| miRNA: |
hsa-miR-224 |
| Disease: |
hepatocellular carcinoma (HCC) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
API-5 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-224, which is up-regulated in the tumors of HCC patients, sensitizes cells to apoptosis through
the inhibition of API-5 at the mRNA levels and increases cell proliferation. Significantly, miR-224 expression was found to be inversely correlated with API-5 expression in HCC patients. |
Reference:
Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target. | PMID:18319255
Wang Y, Lee AT, Ma JZ, Wang J, Ren J, Yang Y, Tantoso E, Li KB, Ooi LL, Tan P, Lee CG.
J Biol Chem. 2008 May 9;283(19):13205-15. Epub 2008 Mar 4. |
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