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Thursday, May.2, 2024
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| miRNA: |
hsa-miR-27a |
| Disease: |
breast cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
ZBTB10, Myt-1 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: The oncogenic activity of miR-27a in MDA-MB-231 cells is due, in part, to suppression of ZBTB10 and Myt-1, which regulate specificity protein transcription factors and the G2-M chechpoint in MDA-MB-231 breast cancer Cells. |
Reference:
The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. | PMID:18006846
Mertens-Talcott SU, Chintharlapalli S, Li X, Safe S.
Cancer Res. 2007 Nov 15;67(22):11001-11. |
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