Description: Translocations involving HMGA2 and numerous translocation partners.These translocations generate a truncated HMGA2 mRNA lacking the let-7 complementary sites of the wild-type mRNA and are associated with the indicated tumors. In its 3'UTR, human HMGA2 has seven let-7 complementary sites, all of which are conserved in the mouse, rat, dog, and chicken. |