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Thursday, May.2, 2024
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| miRNA: |
hsa-let-7a |
| Disease: |
breast cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
RAS, HMGA2 |
Validated targets of miRNA from TarBase: |
NF2 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Increased let-7 paralleled reduced H-RAS and HMGA2, known let-7 targets. Silencing H-RAS in a breast tumor-initiating cells(BTIC)- enriched cell line reduced self renewal but had no effect on differentiation, while silencing HMGA2 enhanced differentiation but did not affect self renewal. Therefore let-7 regulates multiple BT-IC stem cell-like properties by silencing more than one target. |
Reference:
let-7 regulates self renewal and tumorigenicity of breast cancer cells. | PMID:18083101
Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J, Song E.
Cell. 2007 Dec 14;131(6):1109-23. |
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