| miRNA: |
hsa-miR-29b |
| Disease: |
cholangiocarcinoma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
Mcl-1 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Mcl-1 protein expression can be regulated by mir-29b. Enforced mir-29b expression reduced Mcl-1 cellular protein levels and sensitized the cancer cells to tumor necrosis factor-related apoptosisinducing ligand (TRAIL) cytotoxicity. Transfection of non-malignant cells (that express high levels ofmir -29) with a locked-nucleic acid antagonist ofmir-29b increased
Mcl-1 levels and reduced TRAIL-mediated apoptosis. Thus mir-29 is an endogenous regulator ofM cl-1 protein expression, and thereby, apoptosis. |
Reference:
mir-29 regulates Mcl-1 protein expression and apoptosis. | PMID:17404574
Mott JL, Kobayashi S, Bronk SF, Gores GJ.
Oncogene. 2007 Sep 13;26(42):6133-40. Epub 2007 Apr 2. |
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