hsa-miR-29b

chronic lymphocytic leukemia (CLL)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

Tcl1

Validated targets of miRNA from TarBase:

unknown : More...

Description:

miR-29b and miR-181b target oncogene TCL1, which leads to malignant cell proliferation.

Reference:

The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia. | PMID:17707831
Calin GA, Pekarsky Y, Croce CM.
Best Pract Res Clin Haematol. 2007 Sep;20(3):425-37.