hsa-let-7a

gastric cancer (stomach cancer)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

HMGA2

Validated targets of miRNA from TarBase:

NF2 : More...

Description:

High expression of HMGA2 in gastric cancer correlates with tumor invasiveness and is an independent prognostic factor. Furthermore, our findings suggest that HMGA2 is negatively regulated by the let-7 miRNA family in human gastric cancer.

Reference:

Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family. | PMID:18413822
Motoyama K, Inoue H, Nakamura Y, Uetake H, Sugihara K, Mori M.
Clin Cancer Res. 2008 Apr 15;14(8):2334-40.