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Monday, Apr.29, 2024
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| miRNA: |
hsa-miR-29c |
| Disease: |
type 2 diabetes |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Adenovirus-mediated overexpression of miR-29a, miR-29b and miR-29c in rat adipocytes largely repressed insulin-stimulated glucose uptake, revealing a crucial role of miR-29 in type 2 diabetes. |
Reference:
Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. | PMID:17652184
He A, Zhu L, Gupta N, Chang Y, Fang F.
Mol Endocrinol. 2007 Nov;21(11):2785-94. Epub 2007 Jul 24. |
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