hsa-let-7a

lipoma

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

normal

Validated targets of miRNA from the reference:

HMGA2

Validated targets of miRNA from TarBase:

NF2 : More...

Description:

Translocations involving HMGA2 and numerous translocation partners.These translocations generate a truncated HMGA2 mRNA lacking the let-7 complementary sites of the wild-type mRNA and are associated with the indicated tumors. In its 3'UTR, human HMGA2 has seven let-7 complementary sites, all of which are conserved in the mouse, rat, dog, and chicken.

Reference:

Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. | PMID:17322030
Mayr C, Hemann MT, Bartel DP.
Science. 2007 Mar 16;315(5818):1576-9. Epub 2007 Feb 22.