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Friday, May.3, 2024
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| miRNA: |
hsa-let-7a |
| Disease: |
lung cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
NF2 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: reduced let-7 expression is significantly associated with shortened postoperative survival and that overexpression of let-7 results in the inhibition of lung cancer cell growth. |
Reference:
Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. | PMID:15172979
Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y, Mitsudomi T, Takahashi T.
Cancer Res. 2004 Jun 1;64(11):3753-6. |
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