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Friday, May.3, 2024
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| miRNA: |
hsa-let-7a |
| Disease: |
lung cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
RAS |
Validated targets of miRNA from TarBase: |
NF2 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Overexpression of let-7 can inhibit lung tumor cell line growth.the expression of the RAS oncogene is regulated by let-7, and RAS is significantly overexpressed in lung tumor samples strongly implicate let-7 as a tumor suppressor in lung tissue and suggests a possible mechanism. |
Reference:
RAS is regulated by the let-7 microRNA family. | PMID:15766527
Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ.
Cell. 2005 Mar 11;120(5):635-47. |
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