| miRNA: |
hsa-miR-320 |
| Disease: |
homozygous sickle cell disease (HbSS) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
CD71 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-320 played an important role for the down-regulation of its target gene, CD71 during reticulocyte terminal differentiation. Further investigation revealed that poor expression of miR-320 in HbSS cells was associated with their defective downregulation CD71 during terminal differentiation. |
Reference:
The genomic analysis of erythrocyte microRNA expression in sickle cell diseases. | PMID:18523662
Chen SY, Wang Y, Telen MJ, Chi JT.
PLoS ONE. 2008 Jun 4;3(6):e2360. |
|
|
