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Tuesday, May.7, 2024
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miRNA: |
hsa-let-7a |
Disease: |
chronic lymphocytic leukemia (CLL) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
NF2 : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: let-7a is conserved broadly in many animal species with higher levels in differentiated normal cells and to be decreased in tumoral undifferentiated cells. |
Reference:
Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis. | PMID:17989717
Marton S, Garcia MR, Robello C, Persson H, Trajtenberg F, Pritsch O, Rovira C, Naya H, Dighiero G, Cayota A.
Leukemia. 2008 Feb;22(2):330-8. Epub 2007 Nov 8. |
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