| miRNA: |
hsa-miR-346 |
| Disease: |
follicular thyroid carcinoma (FTC) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
EFEMP2 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Two specific miRNAs, miR-197 and miR-346, are significantly overexpressed in FTC. In vitro overexpression of either miRNA induces proliferation, whereas inhibition leads to growth arrest. |
Reference:
A limited set of human MicroRNA is deregulated in follicular thyroid carcinoma. | PMID:16822819
Weber F, Teresi RE, Broelsch CE, Frilling A, Eng C.
J Clin Endocrinol Metab. 2006 Sep;91(9):3584-91. Epub 2006 Jul 5. |
|
|
