hsa-miR-34a

colorectal cancer

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

up-regulated

Validated targets of miRNA from the reference:

E2F

Validated targets of miRNA from TarBase:

E2F3 : More...

Description:

miR-34a functions as a potent suppressor of cell proliferation through modulation of the E2F signaling pathway. Abrogation of miR-34a function could contribute to aberrant cell proliferation, leading to colon cancer development.

Reference:

Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. | PMID:17875987
Tazawa H, Tsuchiya N, Izumiya M, Nakagama H.
Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15472-7. Epub 2007 Sep 17.