| miRNA: |
hsa-miR-34a |
| Disease: |
neuroblastoma (NB) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
E2F3 |
Validated targets of miRNA from TarBase: |
E2F3 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Reintroduction of this miRNA into three different NB cell lines causes a dramatic reduction in cell proliferation through the induction of a caspase-dependent apoptotic pathway. miR-34a directly targets the messenger ribonucleic acid (mRNA) encoding E2F3 and significantly reduces the levels of E2F3 protein, a potent transcriptional inducer of cell-cycle progression. |
Reference:
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. | PMID:17297439
Welch C, Chen Y, Stallings RL.
Oncogene. 2007 Jul 26;26(34):5017-22. Epub 2007 Feb 12. |
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