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Friday, Apr.26, 2024
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| miRNA: |
hsa-miR-34a |
| Disease: |
pancreatic cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
BIRC3,DcR3,BCL2 |
Validated targets of miRNA from TarBase: |
E2F3 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: One important role of miR-34a is the modulation and fine-tuning of the gene expression program initiated by p53 for miR-34a-responsive genes are highly enriched for those that regulate cell-cycle progression, apoptosis, DNA repair, and angiogenesis. |
Reference:
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. | PMID:17540599
Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M, Ferlito M, Lowenstein CJ, Arking DE, Beer MA, Maitra A, Mendell JT.
Mol Cell. 2007 Jun 8;26(5):745-52. Epub 2007 May 31. |
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