Friday, Mar.29, 2024
miRNA:

hsa-miR-34b

Disease:

non-small cell lung cancer (NSCLC)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

down-regulated

Validated targets of miRNA from the reference:

BCL2

Validated targets of miRNA from TarBase:

unknown : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

BCL2 is regulated directly by miR-34.The expression of two miR-34s is dramatically reduced in 6 of 14 (43%) non-small cell lung cancers (NSCLCs) and that the restoration of miR-34 expression inhibits growth of NSCLC cells.

 

 

Reference:

p53-mediated activation of miRNA34 candidate tumor-suppressor genes. | PMID:17656095
Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, Zhai Y, Giordano TJ, Qin ZS, Moore BB, MacDougald OA, Cho KR, Fearon ER.
Curr Biol. 2007 Aug 7;17(15):1298-307. Epub 2007 Jul 26.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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