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Friday, Mar.29, 2024
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miRNA: |
hsa-miR-34b |
Disease: |
Oral Squamous Cell Carcinoma (OSCC) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Four of miRNAs (i.e., miR-34b, miR-137, miR-193a, and miR-203) located around CpG islands.The expression of those four genes was restored by treatment with 5-aza-2'-deoxycytidine in OSCC cells lacking their expression. In addition, expression levels of the four miRNAs were inversely correlated with their DNA methylation status in the OSCC lines. In primary tumors of OSCC with paired
normal oral mucosa, down-regulation of miRNA expression through tumor-specific hypermethylation was more frequently
observed for miR-137 and miR-193a than for miR-34b and miR-203. |
Reference:
Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. | PMID:18381414
Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J.
Cancer Res. 2008 Apr 1;68(7):2094-105. |
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