hsa-miR-373

testicular germ cell tumor

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

up-regulated

Validated targets of miRNA from the reference:

LATS2

Validated targets of miRNA from TarBase:

LATS2 : More...

Description:

miR-372 and miR-373 are capable of promoting human cell transformation in collaboration with oncogenic Ras, by inhibiting the expression of the protein kinase LATS2 and sustaining the activity of CDK3.

Reference:

A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. | PMID:16564011
Voorhoeve PM, le Sage C, Schrier M, Gillis AJ, Stoop H, Nagel R, Liu YP, van Duijse J, Drost J, Griekspoor A, Zlotorynski E, Yabuta N, De Vita G, Nojima H, Looijenga LH, Agami R.
Cell. 2006 Mar 24;124(6):1169-81.