Description: All eight miRNAs located in chromosome 14 cluster at Dlk1-Gtl2 Domain(mir-337, mir-432, mir-495,mir-368, mir-376a, mir-376b, mir-377, and mir-419) were expressed in all four IOSE, but in no EOC cell line, which were silenced by epigenetic alterations in EOC. Down-regulation of miRNAs located at Dlk1-Gtl2 domain is associated with higher tumor proliferation and shorter patient survival, suggesting that miRNAs in this cluster function as tumor suppressor genes. |
Reference:
Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. | PMID:18458333
Zhang L, Volinia S, Bonome T, Calin GA, Greshock J, Yang N, Liu CG, Giannakakis A, Alexiou P, Hasegawa K, Johnstone CN, Megraw MS, Adams S, Lassus H, Huang J, Kaur S, Liang S, Sethupathy P, Leminen A, Simossis VA, Sandaltzopoulos R, Naomoto Y, Katsaros D, Gimotty PA, DeMichele A, Huang Q, Butzow R, Rustgi AK, Weber BL, Birrer MJ, Hatzigeorgiou AG, Croce CM, Coukos G.
Proc Natl Acad Sci U S A. 2008 May 13;105(19):7004-9. Epub 2008 May 5. |