Friday, Mar.29, 2024
miRNA:

hsa-miR-377

Disease:

epithelial ovarian cancer (EOC)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

down-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

unknown : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

All eight miRNAs located in chromosome 14 cluster at Dlk1-Gtl2 Domain(mir-337, mir-432, mir-495,mir-368, mir-376a, mir-376b, mir-377, and mir-419) were expressed in all four IOSE, but in no EOC cell line, which were silenced by epigenetic alterations in EOC. Down-regulation of miRNAs located at Dlk1-Gtl2 domain is associated with higher tumor proliferation and shorter patient survival, suggesting that miRNAs in this cluster function as tumor suppressor genes.

 

 

Reference:

Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. | PMID:18458333
Zhang L, Volinia S, Bonome T, Calin GA, Greshock J, Yang N, Liu CG, Giannakakis A, Alexiou P, Hasegawa K, Johnstone CN, Megraw MS, Adams S, Lassus H, Huang J, Kaur S, Liang S, Sethupathy P, Leminen A, Simossis VA, Sandaltzopoulos R, Naomoto Y, Katsaros D, Gimotty PA, DeMichele A, Huang Q, Butzow R, Rustgi AK, Weber BL, Birrer MJ, Hatzigeorgiou AG, Croce CM, Coukos G.
Proc Natl Acad Sci U S A. 2008 May 13;105(19):7004-9. Epub 2008 May 5.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
Please don't hesitate to address comments/questions/suggestions regarding this webpage to: ydwang@hit.edu.cn or yunliu@iu.edu