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Friday, May.3, 2024
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| miRNA: |
hsa-let-7a-3 |
| Disease: |
lung cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: The let-7a-3's putative promoter region is heavily methylated by DNMT1 and DNMT3B in normal human tissues, but hypomethylated in lung adenocarcinomas. Let-7a-3’s promoter demethylation induced reactivation of the gene and increased proliferation in a lung cancer cell lines. |
Reference:
The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. | PMID:17308078
Brueckner B, Stresemann C, Kuner R, Mund C, Musch T, Meister M, Sultmann H, Lyko F.
Cancer Res. 2007 Feb 15;67(4):1419-23. |
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