| miRNA: |
hsa-miR-17-92 |
| Disease: |
Burkitt lymphoma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
E2F1 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-17-92 promotes cell proliferation by shifting the E2F transcriptional balance away from the pro-apoptotic E2F1 and toward the proliferative E2F3 transcriptional network. |
Reference:
Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. | PMID:17135268
Woods K, Thomson JM, Hammond SM.
J Biol Chem. 2007 Jan 26;282(4):2130-4. Epub 2006 Nov 29. |
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