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Monday, May.6, 2024
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| miRNA: |
hsa-miR-17-92 |
| Disease: |
diffuse large B-cell lymphoma (DLBCL) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
E2F1 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: The mir-17-92 polycistron is located in a region of DNA that is amplified in human B-cell lymphomas.Enforced expression of the mir-17-92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. |
Reference:
A microRNA polycistron as a potential human oncogene. | PMID:15944707
He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ, Hammond SM.
Nature. 2005 Jun 9;435(7043):828-33. |
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