hsa-let-7b
lung cancer
Relationship type:
Causal
Detection method for miRNA expression:
Northern blot, qRT-PCR etc
down-regulated
Validated targets of miRNA from the reference:
HMGA2
Validated targets of miRNA from TarBase:
Lin28,Mtpn : More...
Description:
let-7 reduces the expression of HMGA2 and cell proliferation.
Reference:
The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. | PMID:17437991 Lee YS, Dutta A. Genes Dev. 2007 May 1;21(9):1025-30. Epub 2007 Apr 16.