| miRNA: |
hsa-miR-221 |
| Disease: |
glioblastoma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
p27Kip1(CDKN1B) |
Validated targets of miRNA from TarBase: |
KIT : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miRNAs repress the expression of the cell cycle regulator p27Kip1 in glioblastoma cells, and that miRNA 221/ 222, which has previously been shown to be upregulated in glioblastoma, is the specific miRNA responsible for this. |
Reference:
Regulation of p27Kip1 by miRNA 221/222 in glioblastoma. | PMID:17721077
Gillies JK, Lorimer IA.
Cell Cycle. 2007 Jun;6(16):2005-9. Epub 2007 May 31. |
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