hsa-miR-221

non-small cell lung cancer (NSCLC)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

KIT : More...

Description:

A five-microRNA signature (let-7a, miR-221, miR-137, miR-372, and miR-182*) that is associated with survival and cancer relapse in NSCLC patients. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk scores in their microRNA signatures had poor overall and disease-free survivals compared to the low-risk-score patients. This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients.promoted invasiveness of lung cancer cell lines.

Reference:

MicroRNA signature predicts survival and relapse in lung cancer. | PMID:18167339
Yu SL, Chen HY, Chang GC, Chen CY, Chen HW, Singh S, Cheng CL, Yu CJ, Lee YC, Chen HS, Su TJ, Chiang CC, Li HN, Hong QS, Su HY, Chen CC, Chen WJ, Liu CC, Chan WK, Chen WJ, Li KC, Chen JJ, Yang PC.
Cancer Cell. 2008 Jan;13(1):48-57.