|
|
|
|
Friday, May.10, 2024
|
|
|
|
|
|
| miRNA: |
hsa-miR-221 |
| Disease: |
prostate cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
p27Kip1(CDKN1B) |
Validated targets of miRNA from TarBase: |
KIT : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-221/222 can be regarded as a new family of oncogenes, directly targeting the tumor suppressor p27Kip1, and that their overexpression might be one of the factors contributing to the oncogenesis and progression of prostate carcinoma through p27Kip1 down-regulation. |
Reference:
miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. | PMID:17569667
Galardi S, Mercatelli N, Giorda E, Massalini S, Frajese GV, Ciafre SA, Farace MG.
J Biol Chem. 2007 Aug 10;282(32):23716-24. Epub 2007 Jun 14. |
|
|
|
|
|
|
