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Thursday, Apr.18, 2024
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| miRNA: |
hsa-miR-221 |
| Disease: |
hepatocellular carcinoma (HCC) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
KIT : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Three of the deregulated miRNAs (miR-221, let-7a-1, and miR-122a) were further assayed by Northern blot and quantitative realtime RT-PCR for validation purposes.Overall, Northern blot analysis revealed that miR-221 was up-regulated in 83% of HCCs when compared with matched cirrhotic tissue, let-7a-1 was down-regulated in 70% of HCCs, and miR-122a resulted down-regulated in 70%
of HCCs. |
Reference:
Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. | PMID:17616664
Gramantieri L, Ferracin M, Fornari F, Veronese A, Sabbioni S, Liu CG, Calin GA, Giovannini C, Ferrazzi E, Grazi GL, Croce CM, Bolondi L, Negrini M.
Cancer Res. 2007 Jul 1;67(13):6092-9. |
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