Friday, Mar.29, 2024
miRNA:

hsa-miR-152

Disease:

asthma

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

normal

Validated targets of miRNA from the reference:

HLA-G

Validated targets of miRNA from TarBase:

unknown : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

+3142C/G influences miRNA targeting of HLA-G and is associated with risk of asthma.Interestingly, the three miRNA genes are located at regions that have been linked to asthma or IgE: 7p15(miR-148a), 12q13(miR-148b), and 17q21(miR-152), raising the possibility that variation in the miRNA genes themselves might contribute to asthma risk, perhaps by interacting with HLA-G.

 

 

Reference:

Allele-specific targeting of microRNAs to HLA-G and risk of asthma. | PMID:17847008
Tan Z, Randall G, Fan J, Camoretti-Mercado B, Brockman-Schneider R, Pan L, Solway J, Gern JE, Lemanske RF, Nicolae D, Ober C.
Am J Hum Genet. 2007 Oct;81(4):829-34. Epub 2007 Aug 20.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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