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Friday, Mar.29, 2024
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miRNA: |
hsa-miR-152 |
Disease: |
asthma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
normal |
Validated targets of miRNA from the reference: |
HLA-G |
Validated targets of miRNA from TarBase: |
unknown : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: +3142C/G influences miRNA targeting of HLA-G and is associated with risk of asthma.Interestingly,
the three miRNA genes are located at regions that have been linked to asthma or IgE: 7p15(miR-148a), 12q13(miR-148b), and 17q21(miR-152), raising the possibility that variation in the miRNA genes themselves might contribute to asthma risk, perhaps by interacting with HLA-G. |
Reference:
Allele-specific targeting of microRNAs to HLA-G and risk of asthma. | PMID:17847008
Tan Z, Randall G, Fan J, Camoretti-Mercado B, Brockman-Schneider R, Pan L, Solway J, Gern JE, Lemanske RF, Nicolae D, Ober C.
Am J Hum Genet. 2007 Oct;81(4):829-34. Epub 2007 Aug 20. |
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