| miRNA: |
hsa-miR-155 |
| Disease: |
diffuse large B-cell lymphoma (DLBCL) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
hAT1R |
Validated targets of miRNA from TarBase: |
AGTR1 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-155 can bind to the 3'-untranslated region(UTR) of hAT(1)R mRNAs and translationally repress the expression of this protein in vivo. Importantly, the translational repression mediated by miR-155 can be regulated by physiological stimuli. |
Reference:
MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts. | PMID:16675453
Martin MM, Lee EJ, Buckenberger JA, Schmittgen TD, Elton TS.
J Biol Chem. 2006 Jul 7;281(27):18277-84. Epub 2006 May 4. |
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