Friday, Mar.29, 2024
miRNA:

hsa-miR-155

Disease:

myeloproliferative disorder

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

up-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

AGTR1 : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

miR-155 expression is greatly increased in mouse bone marrow cells after LPS injection and is suffi cient to drive GM expansion when constitutively expressed in mouse HSCs in vivo. However, sustained expression of miR-155 also leads to several features characteristic of pathological myeloid proliferations, correlating with its overexpression in samples from human acute myeloid leukemia (AML) patients. Finally, miR-155 directly repressed a broad range of target mRNAs implicated in myeloid hyperplasia and/or hematopoiesis.

 

 

Reference:

Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. | PMID:18299402
O'Connell RM, Rao DS, Chaudhuri AA, Boldin MP, Taganov KD, Nicoll J, Paquette RL, Baltimore D.
J Exp Med. 2008 Mar 17;205(3):585-94. Epub 2008 Feb 25.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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