|
|
|
|
Friday, May.17, 2024
|
|
|
|
|
|
| miRNA: |
hsa-miR-1 |
| Disease: |
coronary artery disease |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
GAJ1,KCNJ2 |
Validated targets of miRNA from TarBase: |
GJA1,Hand2,HDAC4,TMSB4X : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-1 overexpression slowed conduction and depolarized the cytoplasmic membrane by post-transcriptionally repressing KCNJ2 and GJA1 and this likely accounts at least in part for its arrhythmogenic potential. Thus, miR-1 may have important pathophysiological functions in the heart, and is a potential antiarrhythmic target. |
Reference:
The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. | PMID:17401374
Yang B, Lin H, Xiao J, Lu Y, Luo X, Li B, Zhang Y, Xu C, Bai Y, Wang H, Chen G, Wang Z.
Nat Med. 2007 Apr;13(4):486-91. Epub 2007 Apr 1. |
|
|
|
|
|
|
