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Wednesday, May.8, 2024
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| miRNA: |
hsa-miR-106a |
| Disease: |
colorectal cancer |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
E2F1 |
Validated targets of miRNA from TarBase: |
RB1 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Altered expression of miR-17-5p, miR-106a, and EGFL7 was associated with pathological tumor features of poor prognosis. Downregulation of miR-106a predicted shortened DFS (P=0.03) and OS (P=0.04). miR-17-5p correlated with DFS only at early stages (P=0.07). Inverse correlations were found between miR-17-5p and miR-106a levels and their target expression, E2F1 (P=0.04 and P=0.03, respectively). Inverse correlation between miR-17-5p and miR-106a and E2F1 levels supports E2F1 as a target mRNA for the two miRNAs. |
Reference:
Deregulated expression of miR-106a predicts survival in human colon cancer patients. | PMID:18521848
Diaz R, Silva J, Garcia JM, Lorenzo Y, Garcia V, Pena C, Rodriguez R, Munoz C, Garcia F, Bonilla F, Dominguez G.
Genes Chromosomes Cancer. 2008 Sep;47(9):794-802. |
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