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Saturday, Apr.20, 2024
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miRNA: |
hsa-let-7b |
Disease: |
uveal melanoma |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
Lin28,Mtpn : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: The top six miRNA discriminators ( let-7b, miR-199a,miR-199a*, miR-143, miR-193b, and miR-652) accurately distinguished class 1 (low metastatic risk) from class 2 (high metastatic risk) with 100% sensitivity and specificity. |
Reference:
Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling. | PMID:18477892
Worley LA, Long MD, Onken MD, Harbour JW.
Melanoma Res. 2008 Jun;18(3):184-90. |
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