Friday, Mar.29, 2024
miRNA:

hsa-miR-106a

Disease:

T-cell leukemia

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

up-regulated

Validated targets of miRNA from the reference:

Mylip, Rbp1-like

Validated targets of miRNA from TarBase:

RB1 : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

The authors conclude that, in addition to miR-106a, miR-20b, miR-19b-2, and miR-92-2 overexpression in tumors, their capacity to induce anchorage independence growth strongly supports an oncogenic potential for those miRNAs. they also conclude that Mylip and Rbp1-like are true targets of the miR-106-363 cluster(miR-106a, miR-18b, miR-20b, miR-19b-2, miR-92-2, and miR-363). More specifically, Rbp1-like seemed only targeted by miR-106a/miR-20b, whereas Mylip could be targeted by the four miRNAs(miR-106a, miR-20b, miR-19b-2, and miR-92-2) with miR-106a/miR-20b being more efficient.

 

 

Reference:

Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia. | PMID:17575136
Landais S, Landry S, Legault P, Rassart E.
Cancer Res. 2007 Jun 15;67(12):5699-707.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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