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Thursday, Apr.18, 2024
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| miRNA: |
hsa-miR-106a |
| Disease: |
follicular lymphoma (FL) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
microarray |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
RB1 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Nine miRNAs (hsa-miR-9, hsa-miR-301, hsa-miR-213, hsa-miR-9*, hsa-miR-330, hsa-miR-106a, hsa-miR-338, hsa-miR-155, hsa-miR-210) were significantly up- and three miRNAs (hsa-miR-320, hsa-miR-149, hsa-miR-139) down-regulated in the lymphoma samples. Expression of hsa-miR-9 was most strongly increased (12-fold) and of hsa-miR-320 most strongly decreased (3-fold).A classification tree was
computed using four miRNAs (miR-330, miR-17-5p, miR-106a and miR-210) to correctly identify 98% of all 111 cases that were analysed in this study. |
Reference:
MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas. | PMID:18537969
Roehle A, Hoefig KP, Repsilber D, Thorns C, Ziepert M, Wesche KO, Thiere M, Loeffler M, Klapper W, Pfreundschuh M, Matolcsy A, Bernd HW, Reiniger L, Merz H, Feller AC.
Br J Haematol. 2008 Jun 3. [Epub ahead of print] |
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