Thursday, Mar.28, 2024
miRNA:

hsa-miR-125a

Disease:

neuroblastoma (NB)

Relationship type:

Unspecified

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

down-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

ERBB2,ERBB3,Lin28 : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

Three neuronal miRNAs (9,125a,and 125b) act in an additive manner by repressing a common target, the truncated isoform of the neurotrophin receptor tropomyosin-related kinase C, to control human neuroblastoma cell proliferation.

 

 

Reference:

The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. | PMID:17483472
Laneve P, Di Marcotullio L, Gioia U, Fiori ME, Ferretti E, Gulino A, Bozzoni I, Caffarelli E.
Proc Natl Acad Sci U S A. 2007 May 8;104(19):7957-62. Epub 2007 May 1.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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