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Thursday, Mar.28, 2024
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miRNA: |
hsa-miR-125a |
Disease: |
neuroblastoma (NB) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
ERBB2,ERBB3,Lin28 : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Three neuronal miRNAs (9,125a,and 125b) act in an additive manner by repressing a common target, the truncated isoform of the neurotrophin receptor tropomyosin-related kinase C, to control human neuroblastoma cell proliferation. |
Reference:
The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. | PMID:17483472
Laneve P, Di Marcotullio L, Gioia U, Fiori ME, Ferretti E, Gulino A, Bozzoni I, Caffarelli E.
Proc Natl Acad Sci U S A. 2007 May 8;104(19):7957-62. Epub 2007 May 1. |
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