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Thursday, May.2, 2024
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| miRNA: |
hsa-miR-125b |
| Disease: |
breast cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
Lin28 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-125b, which is down-modulated in breast cancer, is located at chromosome 11q23-24, one of the regions most frequently deleted in breast,ovarian, and lung tumors. The recognition of a bona fide
tumor suppressor gene located at 11q23-24 involved in the pathogenesis of human breast cancer is still lacking. The miR-125b gene establishes itself as an important candidate for this role. |
Reference:
MicroRNA gene expression deregulation in human breast cancer. | PMID:16103053
Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, Menard S, Palazzo JP, Rosenberg A, Musiani P, Volinia S, Nenci I, Calin GA, Querzoli P, Negrini M, Croce CM.
Cancer Res. 2005 Aug 15;65(16):7065-70. |
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