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Thursday, May.2, 2024
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| miRNA: |
hsa-miR-125b |
| Disease: |
breast cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
ERBB2, ERBB3 |
Validated targets of miRNA from TarBase: |
Lin28 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: After retroviral delivery and overexpression of these miRNAs in an ERBB2-amplified and -overexpressing human breast cancer cell line, SKBR3. Overexpression of miR-125a or miR-125b reduced ERBB2 and ERBB3 at both the transcript and protein level in these cells, leading to reduced ERK1/2 and AKT signaling. Functionally, miR-125a or miR-125b-overexpressing SKBR3 cells displayed diminished plating and anchorage-dependent growth in addition to markedly reduced cell migration and invasion capacities. |
Reference:
Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. | PMID:17110380
Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS, Benz CC.
J Biol Chem. 2007 Jan 12;282(2):1479-86. Epub 2006 Nov 16. |
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