hsa-let-7c

uterine leiomyoma (ULM)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

HMGA2

Validated targets of miRNA from TarBase:

unknown : More...

Description:

exogenous Let-7 microRNAs could directly repress the dominant transcript of HMGA2.Let-7 repression of HMGA2 inhibited cellular proliferation.

Reference:

Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma. | PMID:18403645
Peng Y, Laser J, Shi G, Mittal K, Melamed J, Lee P, Wei JJ.
Mol Cancer Res. 2008 Apr;6(4):663-73.