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Friday, Mar.29, 2024
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miRNA: |
hsa-miR-125b-2 |
Disease: |
Down syndrome (DS) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Bioinformatic analyses demonstrate that human chromosome 21(Hsa21) harbors five miRNA genes; miR-99a, let-7c, miR-125b-2, miR-155, and miR-802. MiRNA expression profiling, miRNA RT-PCR, and miRNA in situ hybridization experiments demonstrate that these miRNAs are overexpressed in fetal brain and heart specimens from individuals with DS when compared with age- and sex-matched controls. |
Reference:
Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. | PMID:18387358
Kuhn DE, Nuovo GJ, Martin MM, Malana GE, Pleister AP, Jiang J, Schmittgen TD, Terry AV Jr, Gardiner K, Head E, Feldman DS, Elton TS.
Biochem Biophys Res Commun. 2008 Jun 6;370(3):473-7. Epub 2008 Apr 1. |
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