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Friday, May.3, 2024
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| miRNA: |
hsa-miR-126 |
| Disease: |
non-small cell lung cancer (NSCLC) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
CRK |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Increased expression of Crk has been described in lung cancer and associated with increased tumor invasiveness. Crk is a predicted putative target gene for miR-126. Over-expression of miR126 in a lung cancer cell line resulted in a decrease in Crk protein without any alteration in the associated mRNA. These lung cancer cells exhibit a decrease in adhesion, migration, and invasion. Decreased cancer cell invasion was also evident following targeted knockdown of Crk. MiR-126 alters lung cancer cell phenotype by inhibiting adhesion, migration, and invasion and the effects on invasion may be partially mediated through Crk regulation. |
Reference:
MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. | PMID:18602365
Crawford M, Brawner E, Batte K, Yu L, Hunter MG, Otterson GA, Nuovo G, Marsh CB, Nana-Sinkam SP.
Biochem Biophys Res Commun. 2008 Sep 5;373(4):607-12. Epub 2008 Jul 3. |
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