hsa-miR-146a

breast cancer

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

up-regulated

Validated targets of miRNA from the reference:

IRAK1, TRAF6

Validated targets of miRNA from TarBase:

unknown : More...

Description:

NF-kB can induce the expression of miR-146a, which can then down-regulate IRAK1 and TRAF6 and thus acts as a component in a negative feedback loop that controls TLR signaling.

Reference:

NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. | PMID:16885212
Taganov KD, Boldin MP, Chang KJ, Baltimore D.
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12481-6. Epub 2006 Aug 2.